Objectives: To develop a robust knowledge and familiarity with the methods used in clinical research and pharmacoepidemiology to evaluate the efficacy and effectiveness of medicines and therapeutic interventions. To develop a robust knowledge and familiarity with the methods used in randomised clinical trials. To analyse and discuss ethical and legal issues in clinical research and randomised clinical trials. To understand principles of synthesizing scientific data through systematic review and meta-analysis of clinical trials. To acquire a specialised and robust knowledge of specialized requisites in the design and interpretation of clinical trials in specific areas Topics covered: Scientific methods and causality. Statistical and methodological issues for the design and analysis of clinical trials. Ethical issues in the development of clinical research and clinical trials. Systematic review and meta-analysis of randomised clinical trials. Other methods for the evaluation of the effectiveness of medicines and therapeutic interventions.