As
regards LABAs’ effects on GRs, they have been suggested
to prime GRs and affect
their nuclear localisation.
In fact β2-agonists
seem to favour, via specific phosphorylating enzyme
called mitogen-activated protein kinases (MAPKs),
the phosporylation
of particular aminoacids
of GRs. This process induces conformational modifications
of GRs that increase receptor sensitivity to steroid-dependent
activation.13
In addition, other studies have demonstrated that
translocation of GRs from
the cytosol to the nucleus of the cell, a fundamental
step in the anti-inflammatory
activity of corticosteroids, is increased by the
addition of a LABA.14,15
β2-agonists
may also increase the sensitivity of the molecular
pathways that are utilised by corticosteroids to
suppress inflammation.
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